Journal: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

Article Title: A Comparison between Direct and Indirect Measurements of Neurotransmitter Vesicle Release Dynamics: A computational Study

doi: 10.1109/EMBC.2014.6943800

Figure Lengend Snippet: Simulations using the EONS functional model. (a) Representation of the EONs functional model and simulation techniques for estimating vesicle release rate. Postsynaptic responses were analyzed similar to the experimental setup as explained in Fig 1. The Functional EONS model utilizes the FD model calibrated from Fig. 1 and AMPA receptor models based on AMPA receptor kinetics. (b) comparison between the simulated release rate from the FD model (solid) and the inferred release rate from the kernel estimation of the postsynaptic response (dotted). (c) uses the same setup as (a) except that the kinetics of the AMPA receptors were modified such that AMPA receptor desensitization was inhibited (results shown in the dash-dotted line).

Article Snippet: Future applications of the EONS functional model will therefore include incorporation into large scale models while preserving the complex nonlinear dynamics of synapses, leading to the implementation of more complete map of the brain's mechanistic properties.

Techniques: Functional Assay, Comparison, Modification